Jennifer Kesse was 24 years old when she disappeared from Orlando, Florida, on the morning of January 24, 2006. Her case quickly became one of the most well-known missing person investigations in the country and remains unsolved nearly two decades later.

Jennifer had recently returned from a vacation with her boyfriend and was preparing for another workday. She lived alone at the Mosaic at Millenia condominium complex, where many units were undergoing renovations. Construction workers were regularly present on the property, and several worked in and around the complex each day.

On the morning of January 24, Jennifer spoke with both her boyfriend and members of her family before leaving for work. She was expected at her job as a financial analyst with Central Florida Investments but never arrived. When she failed to answer her phone throughout the day, her family became increasingly concerned. After contacting her employer and confirming she had never shown up, her parents drove to Orlando to check on her. They found her condominium locked, with nothing appearing to be disturbed. Her car, a black 2004 Chevrolet Malibu, was gone, along with Jennifer.

Two days later, Jennifer's car was found abandoned at the Huntington on the Green apartment complex, about a mile from her condominium. Witnesses reported seeing someone park the vehicle around noon on the day she disappeared. Surveillance cameras captured a person walking away from the car, but by an extraordinary coincidence, the individual was obscured by the fence posts in every frame of the video. Investigators have described it as one of the most frustrating pieces of surveillance footage they have ever encountered because the person's face was never visible.

Evidence recovered from Jennifer's vehicle included a latent fingerprint and a small amount of DNA. Neither has ever been matched to a suspect. Jennifer's family has stated that several personal items normally carried by her, including her purse, keys, cell phone, and iPod, have never been recovered.

Over the years, investigators have explored numerous theories. Early attention focused on construction workers at Jennifer's condominium complex because many had access to the property and some reportedly had not been fully identified by contractors. Law enforcement interviewed many individuals connected to the complex, but no one has ever been charged in connection with Jennifer's disappearance. Authorities have never publicly identified an official suspect or announced what they believe happened to her.

In 2018, Jennifer's family won a lengthy legal battle to obtain the complete investigative file from the Orlando Police Department and the Florida Department of Law Enforcement. The family hired private investigators to reexamine the evidence, conduct new interviews, and pursue leads that had not previously been explored. Despite those efforts, Jennifer has never been found, and the investigation remains active.

Jennifer's disappearance continues to receive national attention through documentaries, podcasts, and television programs. Her family has never stopped searching for answers and continues to encourage anyone with information, no matter how small, to come forward.

Anyone with information about Jennifer Kesse's disappearance is urged to contact the Florida Department of Law Enforcement at 1-888-356-4774 or the Orlando Police Department at 407-246-2470. Anonymous tips may also be submitted to Crimeline at 1-800-423-TIPS (8477).